Sperm immunoglobulin G (IgG) concentration
This test measures the amount of Immunoglobulin G (IgG), a type of antibody found in semen. IgG plays a role in immune function and may be assessed in certain fertility evaluations.
["IgG in sperm can help assess immune-related factors in fertility."]
Key facts at a glance
- LOINC
- 106117-5
- Short code
- Sperm IgA+IgG NFr Smn
- Synonyms
- Sperm IgA+IgG NFr Smn
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82784
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why Might This Test Be Ordered?
Your healthcare provider may recommend this test if you or your partner are experiencing unexplained infertility, recurrent pregnancy loss, or if there are concerns about immune-mediated issues affecting fertility. IgG levels in semen can sometimes indicate how well sperm are protected or supported by antibodies, which may influence reproductive health.
What Does the Test Involve?
A semen sample is collected through masturbation or by other approved methods, then analyzed in a lab to measure IgG concentration. The sample is typically processed and tested using immunoassay techniques to detect antibody presence.
What Do Results Mean?
Results are not typically provided as a single reference range for sperm IgG, as levels can vary widely based on individual health, immune status, and other factors. Instead, your provider will interpret results in the context of your clinical situation, such as comparing IgG levels to baseline or other fertility markers.
Preparation and Sample Collection
No special preparation is needed. Semen should be collected in a sterile container, and timing may depend on your provider’s instructions to ensure accurate results. Avoid ejaculation for a specified period (often 2–5 days) if directed.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
IgG in Sperm
Frequently asked questions
IgG in semen can be relevant if there are concerns about autoimmunity, immune-mediated infertility, or sperm viability. Elevated or altered IgG levels might suggest immune responses that could impact fertility, though this is not always the case. Your provider will discuss findings in relation to your symptoms and medical history.
How long does it take to get results? Results are typically available within 1–3 business days, depending on lab processing times. Follow-up with your healthcare provider to discuss findings.
Is this test covered by insurance? Coverage depends on your insurance plan and the clinical indication. Check with your provider or insurance company to confirm if this test is approved for your specific situation.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy