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Spermine concentration in semen

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of spermine, a polyamine compound found in semen, which plays a role in sperm motility and viability.

Quick summary

["Understanding your spermine levels may help assess fertility or sperm health."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96732-3
Short code
Spermine Smn Micro
Synonyms
Spermine Smn Micro
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you or your partner are experiencing difficulty conceiving, unexplained infertility, or if sperm analysis is part of a broader fertility evaluation. It may also be used in research or specialized clinical settings to study sperm function.

What to Expect Before the Test

No special preparation is typically required. You may need to provide a semen sample, often collected through masturbation into a sterile container, usually at a clinic or lab. Follow your provider’s instructions carefully.

How the Test Works

Semen is analyzed using a specialized laboratory technique, often high-performance liquid chromatography (HPLC), to measure the concentration of spermine. This involves breaking down semen components and identifying the specific compound.

What the Results Mean

Results are reported as a concentration value (e.g., micrograms per milliliter). While specific reference ranges aren’t universally standardized, lower spermine levels may indicate potential issues with sperm function or motility, which could impact fertility.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Semen Spermine Level

Frequently asked questions

What does my spermine level tell me about my health?
Spermine levels in semen can be part of a broader evaluation for fertility issues. Abnormally low levels may suggest underlying problems with sperm production, motility, or health, but they are not the sole determinant of fertility. Always discuss results with your healthcare provider for personalized insights.
Can spermine levels change over time?
Yes, spermine levels can vary based on factors like age, overall health, diet, and exposure to environmental toxins. Stress, infections, or certain medications may also influence results. Regular monitoring may be needed if fertility concerns persist.
Is this test covered by insurance?
Coverage depends on your insurance plan and the reason for testing. If ordered for fertility evaluation, check with your provider or insurance company to confirm coverage details before proceeding.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy