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Sperm Head Morphology Analysis (Quantitative)

Published: August 9, 2026Updated: August 17, 2026

This test examines the shape and structure of sperm cells in your semen sample to assess sperm head integrity, which is important for fertility.

Quick summary

["Your sperm head shape can affect fertility and may indicate underlying reproductive health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
48372-7
Short code
Sperm Isolated Head NFr Smn
Synonyms
Sperm Isolated Head NFr Smn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
135
Ref high
980
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82626
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test evaluates the proportion of sperm with normal head shapes, which are essential for fertilizing an egg. Abnormal sperm heads may suggest genetic, infectious, or other health factors affecting fertility.

Why It’s Done

A doctor may order this test if you or your partner have trouble getting pregnant, unexplained infertility, or recurrent pregnancy loss. It helps identify whether sperm head abnormalities are contributing to fertility challenges.

Sample Collection and Preparation

You’ll provide a semen sample (usually collected via masturbation) in a sterile container. The sample is then processed to isolate sperm cells, and their heads are analyzed under a microscope for shape and size.

What to Expect Before the Test

Avoid ejaculation for 2–3 days before testing to ensure a representative sample. Wear loose clothing and follow any specific instructions your healthcare provider gives.

Reference range

NCBI: DHEA-S Male 135-980 µg/dL; Female 30-260 µg/dLN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal sperm head morphology may indicate conditions like genetic disorders, infections, or exposure to toxins. While not all cases of infertility are due to sperm head issues, this test can help pinpoint potential causes for further evaluation.

Frequently asked questions

How long does it take to get results?
Results are typically available within 1–2 weeks after the sample is processed. Your healthcare provider will discuss findings in relation to your fertility history and symptoms.
Can lifestyle changes improve sperm head quality?
Yes, certain lifestyle changes—such as avoiding smoking, limiting alcohol, maintaining a healthy weight, and reducing exposure to environmental toxins—may support sperm health. However, this test alone doesn’t diagnose underlying causes; further evaluation may be needed.
Is this test covered by insurance?
Coverage depends on your insurance plan and reason for testing. Check with your provider or insurance company to confirm if this test is included under fertility-related evaluations.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy