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Progesterone, Serum (Total)

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of progesterone, a hormone critical for reproductive health, in your blood serum. Progesterone helps regulate the menstrual cycle, supports pregnancy, and influences fertility.

Quick summary

["Progesterone levels can help diagnose hormonal imbalances, track ovulation, or assess fertility issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
38500-5
Short code
Sperm Prog 1 NFr Smn
Synonyms
Sperm Prog 1 NFr Smn
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like irregular periods, infertility, or suspected hormonal disorders. It’s also used in fertility treatments to monitor ovulation or pregnancy support.

What to Expect Before the Test

No special preparation is needed, but you may be asked to fast for 8–12 hours before the draw if your lab requires it. Bring your lab requisition to your appointment.

How the Test Works

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure progesterone concentration using an immunoassay method.

What the Results Mean

Results are compared to general reference ranges, but your provider will interpret them in the context of your medical history and symptoms. Low levels may indicate ovulation issues, while high levels could suggest pregnancy or other hormonal conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total Serum Progesterone

Frequently asked questions

How often will I need this test?
This test may be repeated at different times during your menstrual cycle (e.g., mid-cycle for ovulation tracking) or as part of ongoing fertility evaluations. Follow your provider’s specific instructions for timing.
What if my results are outside the normal range?
If your results are abnormal, your provider will discuss potential causes, such as hormonal imbalances, thyroid issues, or medical conditions. They may recommend further testing or adjustments to treatment.
Can I eat or drink before this test?
Check with your lab or provider about fasting requirements, as some tests require an 8–12 hour fast before drawing blood.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy