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Autoantibody Profile to Screen for Systemic Lupus Erythematosus (SLE) and Related Autoimmune Conditions

Published: August 9, 2026Updated: August 16, 2026

This test measures several antibodies that may indicate an autoimmune condition, such as lupus or other inflammatory diseases. It helps your healthcare provider assess whether your symptoms could be linked to an immune system dysfunction.

Quick summary

["This screening can help identify potential autoimmune activity that may require further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53326-5
Short code
Sp Gr Ur Strip.auto
Synonyms
Sp Gr Ur Strip.auto
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
test-strip-automated
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test includes antibodies against common targets found in autoimmune diseases, such as nuclear antigens (e.g., double-stranded DNA, Smith antigen) and cytoplasmic proteins (e.g., Ro/SSA, La/SSB, Sm). Some tests may also check for antibodies against phospholipids or other specific markers depending on the panel.

Why It’s Done

Your doctor may order this test if you have symptoms like joint pain, fatigue, rash, fever, or other signs of an autoimmune disease. It’s often used as part of an initial evaluation or to monitor disease activity in patients already diagnosed with conditions like lupus.

What to Expect Before the Test

No special preparation is usually needed, but you may be asked to fast for 8–12 hours before drawing blood if certain components of the panel require fasting (e.g., some lipid-related markers). Bring your medical records if you’ve had this test before.

What to Expect During the Test

A healthcare provider will draw blood from a vein in your arm. You may feel a slight pinch or discomfort, but it’s usually over quickly. The test itself takes a few minutes, and you can resume normal activities afterward.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Autoimmune Disease Screen

Frequently asked questions

How often should I get this test?
This test is typically done once as part of an initial evaluation or if you have symptoms. If you’re already diagnosed with an autoimmune condition, your doctor may recommend follow-up testing every few months or as needed to monitor disease activity.
What does a ‘positive’ result mean?
A ‘positive’ result means your blood contains antibodies against certain proteins that are often linked to autoimmune diseases. This doesn’t confirm a diagnosis alone—your doctor will review the results with your symptoms and other tests to guide next steps.
Can I take medications before this test?
Yes, you can take your usual medications as directed. Some autoimmune medications (e.g., steroids) may affect antibody levels, but your doctor will consider this when interpreting results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy