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Red Blood Cell Morphology Examination (Specifically Evaluating Spherocytes)

Published: August 9, 2026Updated: August 16, 2026

This test examines red blood cells (RBCs) under a microscope to check for abnormal shapes, such as spherocytes, which are smaller and lack a central pallor. Spherocytes may indicate conditions like hereditary spherocytosis or autoimmune hemolytic anemia.

Quick summary

["Spherocytes can signal underlying blood disorders that may require further medical evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53971-8
Short code
Spherocytes UrnS Ql Micro
Synonyms
Spherocytes UrnS Ql Micro
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test if you have symptoms like fatigue, jaundice, or unexplained anemia. It’s also used to diagnose or monitor conditions affecting red blood cells, such as certain blood disorders or reactions to certain medications.

What to Expect Before the Test

No special preparation is needed. A simple blood draw from a vein in your arm is all that’s required. The sample is then examined under a microscope to count and identify spherocytes among other red blood cells.

What the Results Mean

The test result compares the number of spherocytes to the total red blood cells. An increased proportion of spherocytes may suggest hereditary or acquired blood disorders. Normal results indicate healthy red blood cell morphology.

Common Conditions Linked to Spherocytes

High levels of spherocytes are often associated with hereditary spherocytosis, autoimmune hemolytic anemia, or other conditions that damage red blood cell membranes. Your doctor will correlate these findings with your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: When to Seek Further Evaluation

Short name

Spherocyte Count (Blood Smear Analysis)

Frequently asked questions

What symptoms might trigger this test?
Symptoms like fatigue, pale or yellowish skin, dark urine, or frequent bruising may prompt a doctor to recommend this test to investigate underlying blood disorders.
Can spherocytes be caused by medications?
Yes, certain medications or treatments (e.g., some antibiotics or chemotherapy drugs) can cause red blood cells to become spherocytes. If you suspect medication-related changes, discuss this with your healthcare provider.
How often should I get this test?
Your doctor will determine the frequency based on your condition, symptoms, or treatment plan. Regular monitoring may be needed if you have a known blood disorder or are undergoing treatment for one.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy