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Sphingomyelin in Serum/Plasma (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of sphingomyelin, a type of lipid found in your blood. It may be part of certain diagnostic evaluations.

Quick summary

["Sphingomyelin levels can sometimes be checked for specific medical conditions, though they are not routinely tested in most cases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
49575-4
Short code
Sphingomyelin MFr Amn
Synonyms
Sphingomyelin MFr Amn
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What Is Sphingomyelin?

Sphingomyelin is a phospholipid that plays a role in cell membrane structure and function. While it is present in many tissues, blood levels can be measured to assess metabolic or lipid-related conditions.

Why Might This Test Be Ordered?

Your healthcare provider may order this test if you have symptoms or conditions linked to lipid metabolism disorders, such as certain genetic disorders or rare metabolic diseases. It may also be part of specialized research or diagnostic panels.

How Is the Test Performed?

A blood sample is drawn from a vein, typically in your arm. The sample is then processed to measure sphingomyelin concentration using a specialized laboratory technique, often high-performance liquid chromatography (HPLC).

What Do Results Mean?

Interpretation of sphingomyelin results depends on clinical context, including your medical history and symptoms. Abnormal levels may suggest underlying metabolic or lipid disorders, but reference ranges vary by lab and may not be widely standardized.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Sphingomyelin Level

Frequently asked questions

What causes changes in sphingomyelin levels?
Changes in sphingomyelin levels can be associated with inherited lipid storage disorders, such as Niemann-Pick disease, or other metabolic conditions. Elevated levels may also occur in certain liver or kidney diseases, though this is less common. Always discuss results with your doctor.
How long does it take to get results?
Test results are typically available within 1–3 business days, depending on lab processing times. Your healthcare provider will contact you once results are ready.
Can lifestyle or diet affect sphingomyelin levels?
Dietary factors may indirectly influence lipid metabolism, but sphingomyelin levels are not strongly affected by typical dietary changes. Avoiding alcohol and certain medications (like cholesterol-lowering drugs) may be advised before testing if instructed by your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy