Skip to content

Serotype-Specific Antibody Response to Pneumococcal Serotypes (Serum Immunoglobulin Levels)

Published: August 9, 2026Updated: August 16, 2026

This test measures your immune system’s response to different strains of *Streptococcus pneumoniae* (pneumococcus) bacteria by detecting antibodies in your serum. It helps assess protection against specific serotypes, often used in research or specialized immune monitoring.

Quick summary

["This test evaluates how your body recognizes and fights common pneumonia-causing bacteria strains."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
42361-6
Short code
S pneum 12 serotypes IgG Pnl Ser-mCnc
Synonyms
S pneum 12 serotypes IgG Pnl Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have a history of recurrent infections, immune disorders, or if you’re being studied for vaccine efficacy. It can also help monitor immune function in certain conditions, such as after vaccination or in people with weakened immune systems.

What to Expect Before the Test

No special preparation is needed. A blood sample will be drawn from a vein, usually in your arm. The blood is processed to separate serum, which is then tested for antibodies against specific pneumococcal serotypes.

What the Results Mean

Results show the presence and level of antibodies against each pneumococcal serotype. Higher levels indicate a stronger immune response to that strain. Interpretation depends on clinical context, such as vaccination history or symptoms.

Common Uses and Limitations

This test is primarily used in research, clinical trials, or specialized settings to study immune responses. It’s not a routine diagnostic tool for pneumonia or infections. Results alone don’t diagnose illness but may support broader immune assessments.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Pneumococcal Antibody Profile

Frequently asked questions

How long will it take to get my results?
Results are typically processed within 1–3 business days, depending on lab workflows. Follow-up with your healthcare provider to discuss findings, especially if this test was part of a research or monitoring plan.
What if my antibody levels are low?
Low antibody levels may indicate a weaker immune response to pneumococcal strains, which could be due to vaccination, immune deficiency, or other health factors. Discuss with your provider to explore further testing or preventive measures.
Does this test replace a standard pneumonia screening?
No, this test is specialized for serotype-specific antibody analysis and isn’t a substitute for standard diagnostic tests like chest X-rays or cultures. It’s used alongside other clinical evaluations when needed.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy