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Serum or plasma concentration of pneumococcal antigen (qualitative screening)

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of pneumococcal bacteria in your blood or serum/plasma, often used to identify infections caused by *Streptococcus pneumoniae* (pneumococcus).

Quick summary

["Helps diagnose serious pneumococcal infections quickly."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
11086-6
Short code
S pneum Ag Ser Ql
Synonyms
S pneum Ag Ser Ql
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for specific proteins (antigens) produced by *Streptococcus pneumoniae* bacteria. If these antigens are found, it suggests an active infection. This is typically done using an immunoassay method to detect the presence of these markers in your blood or serum/plasma sample.

Why It’s Done

Your healthcare provider may order this test if you have symptoms like high fever, chills, confusion, difficulty breathing, or signs of pneumonia, sepsis, or meningitis—especially if you’re at higher risk (e.g., elderly, immunocompromised, or with chronic health conditions). It can also be used in certain clinical settings to confirm or monitor suspected pneumococcal infections.

How It Works

A small blood sample is taken from your arm. The serum or plasma portion is then analyzed in a lab using an immunoassay technique to detect pneumococcal antigens. The result is qualitative (positive or negative) rather than quantifying the exact amount of bacteria.

What to Expect Before the Test

No special preparation is needed, but inform your provider if you’re taking blood-thinning medications or have bleeding disorders. Avoid alcohol for 24 hours before testing if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test plays a critical role in diagnosing pneumococcal infections early, which is vital for prompt treatment with antibiotics. Early detection can prevent complications like organ damage, sepsis, or death. It’s particularly useful in high-risk populations where pneumococcal infections are more common.

Short name

Pneumococcal Antigen Screen (Serum/Plasma)

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of pneumococcal antigens in your blood or serum/plasma, strongly suggesting an active pneumococcal infection. Your healthcare provider will work with you to determine the best course of treatment, which may include antibiotics.
What does a negative result mean?
A negative result means no detectable pneumococcal antigens were found in your sample. However, this does not rule out a pneumococcal infection entirely—other tests or clinical evaluation may be needed to confirm or investigate further. Symptoms and medical history will guide next steps.
How often can this test be repeated?
This test is typically done once, but your provider may recommend retesting if symptoms persist or worsen. Repeat testing is usually only needed if initial results are negative but clinical suspicion remains high.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy