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Pneumococcal polysaccharide antibody screening (serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your immune response to pneumococcal bacteria, which can cause serious infections like pneumonia.

Quick summary

["Helps assess if your body has developed protection against pneumococcal strains."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
51472-9
Short code
S pneum CPS IgG Ser-mCnc
Synonyms
S pneum CPS IgG Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects antibodies specific to pneumococcal polysaccharides, which are sugar molecules on the bacterial surface. These antibodies indicate whether your immune system has recognized and responded to pneumococcal exposure.

Why It’s Ordered

Your healthcare provider may recommend this test if you have a history of pneumococcal infections, are at high risk (e.g., elderly, immunocompromised, or with chronic conditions), or are preparing for certain medical procedures.

Sample Collection

A blood sample is drawn from a vein, usually in your arm. The serum portion (liquid part without clots) is used for this test.

Preparation

No special preparation is needed, but inform your provider about any medications or recent illnesses that might affect results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated antibody levels suggest prior exposure to pneumococcal bacteria, which may indicate immunity or past infection. Low or absent levels could mean you lack immunity and may need vaccination or further evaluation.

Short name

Pneumococcal Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result indicates your immune system has produced antibodies against pneumococcal polysaccharides, suggesting some level of protection. However, this does not guarantee immunity against all pneumococcal strains.
Can this test replace vaccination?
No, this test is a screening tool. Vaccination remains the primary way to prevent pneumococcal infections.
How often should I get this test?
This test is typically not routine unless you have specific risk factors. Follow your healthcare provider’s guidance for retesting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy