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Serum or Plasma Substance Concentration for Neutrophil Count (Absolute Neutrophil Count, ANC-related marker)

Published: August 9, 2026Updated: August 16, 2026

This test measures a substance in your blood that helps assess the presence or activity of neutrophils, a type of white blood cell involved in fighting infections.

Quick summary

["Helps evaluate immune response and infection risk by tracking neutrophil-related markers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
86059-3
Short code
S pneum Da 23F Ab Ser-aCnc
Synonyms
S pneum Da 23F Ab Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

This test detects a specific substance in your serum or plasma that correlates with the activity or presence of neutrophils. Neutrophils are a key part of your immune system, helping your body fight off bacteria and infections. The substance measured may be released during inflammation or infection, providing insight into your body’s response to these conditions.

Why It Might Be Ordered

Your healthcare provider may order this test if you have symptoms of infection, such as fever, redness, or swelling, or if you’re at higher risk for infections due to conditions like chemotherapy, diabetes, or immune disorders. It can also be used to monitor treatment progress or check for signs of infection in people with weakened immune systems.

Sample Collection and Preparation

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate the serum or plasma from the cells. This test requires a fresh sample, as the substance being measured can change over time.

What to Expect Before the Test

There are no special preparations needed for this test. You can eat, drink, or take medications as usual. If you’re on blood-thinning medications, let your provider know before the test to avoid unnecessary bleeding.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Elevated levels of this substance may indicate an active infection, inflammation, or immune response. Lower levels could suggest a suppressed immune system or certain medical conditions. This test is often used alongside other blood tests, such as a complete blood count (CBC), to provide a more complete picture of your health status.

Short name

Neutrophil-related substance concentration

Frequently asked questions

How Does This Test Differ from a Complete Blood Count (CBC)?
While a CBC measures your actual neutrophil count directly, this test measures a substance related to neutrophils that can give additional information about their activity or presence without counting the cells themselves.
What Are Common Causes of Abnormal Results?
Abnormal results may be linked to infections (bacterial or fungal), autoimmune diseases, or conditions that affect your immune system. Always discuss any abnormal results with your healthcare provider, as they can help determine the best course of action.
Can This Test Be Used to Diagnose Specific Infections?
No, this test alone cannot diagnose a specific infection. It provides general information about neutrophil activity and is often used alongside other tests, such as cultures or imaging, for a more accurate diagnosis.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy