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Serum or Plasma Substance Concentration for Neopterin (Qualitative/Quantitative)

Published: August 9, 2026Updated: August 16, 2026

Neopterin is a chemical produced by the body in response to inflammation, infection, or immune system activation. Your test measures its presence in your blood.

Quick summary

["Helps assess immune response and potential infections or inflammatory conditions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
86109-6
Short code
S pneum Da 4 IgG Ser-aCnc
Synonyms
S pneum Da 4 IgG Ser-aCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like fever, fatigue, or unexplained infections. It’s also used to monitor conditions like HIV, autoimmune diseases, or infections like tuberculosis.

What to Expect Before the Test

No special preparation is needed, but avoid alcohol for 24 hours before testing. Fasted or non-fasted blood draws are typically acceptable.

How the Test Works

A small blood sample is taken from a vein in your arm. The sample is analyzed to measure neopterin levels using an immunoassay method, which detects the chemical’s presence.

Possible Results and Interpretation

Results are qualitative (positive/negative) or quantitative (exact amount). Elevated levels may indicate immune activation, infection, or inflammation, while normal levels suggest a stable immune response.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Neopterin Level

Frequently asked questions

What Does a Positive or High Neopterin Level Mean?
A positive or elevated result may mean your immune system is overactive or fighting an infection. Your doctor will discuss this with you and may recommend further testing or treatments.
Can Neopterin Levels Change Over Time?
Yes, levels can fluctuate based on your health status, treatments, or infections. Follow-up tests may be needed to track changes and adjust care accordingly.
Does Diet or Medication Affect Neopterin Levels?
Some medications (e.g., immunosuppressants) or infections can influence neopterin levels, but diet alone typically does not. Always discuss medications with your doctor before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy