: Streptococcus pneumoniae Deoxyribonuclease 6B (spnD6B) IgG Antibody, Serum by Multiplex Immunoassay

: What This Test Measures

: Streptococcus pneumoniae is a common bacterium that can cause pneumonia, ear infections, sinus infections, and more serious invasive infections. The test looks for IgG antibodies that your immune system has made against a particular pneumococcal protein (pneumolysin/6B). IgG antibodies generally reflect longer-term or vaccine-related immunity.

: Why a Doctor Might Order It

: Your clinician may order this test to check how your immune system responds to pneumococcal vaccines, to investigate frequent or severe infections, or to evaluate a suspected immune deficiency. It may be done before and after vaccination to see whether antibody levels rise.

: How the Sample Is Collected

: A blood sample is drawn from a vein in your arm and the serum (the clear, liquid part of blood) is separated for testing. The measurement is typically performed by a multiplex immunoassay in a laboratory. No special preparation is usually needed unless your clinician advises otherwise.

: What the Results Mean

: Results are reported as antibody levels against the pneumococcal protein, and interpretation depends on your age, vaccination history, and clinical context. Low or borderline levels may suggest reduced protection or a weaker immune response, while higher levels generally suggest prior exposure or vaccination. Your clinician will interpret results together with other findings; specific cutoffs vary by laboratory.