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Serum or Plasma Mass Concentration of Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called neutrophil gelatinase-associated lipocalin (NGAL), which your body produces in response to kidney stress or damage. It’s often checked to help assess kidney function or injury.

Quick summary

["NGAL helps doctors monitor kidney health, especially after trauma, surgery, or illness."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
26754-2
Short code
S pneum Da 7F Ab Ser-mCnc
Synonyms
S pneum Da 7F Ab Ser-mCnc
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test if you’re at risk for kidney problems, recovering from surgery, have a condition affecting your kidneys, or show early signs of kidney damage, such as reduced urine output or fatigue.

What Does a High or Low Level Mean?

Elevated NGAL levels may indicate kidney stress or damage, especially in cases like acute kidney injury, severe infections, or conditions like heart failure or sepsis. Very low levels are less commonly discussed but could rarely suggest certain genetic or metabolic disorders.

How Is the Test Performed?

A blood sample is taken from a vein in your arm. The blood is then sent to a lab where it’s analyzed to measure NGAL levels using a sensitive detection method.

What Are Common Causes of Abnormal Results?

High NGAL levels can result from kidney problems, infections, heart disease, or other conditions that strain your body’s ability to filter waste. Low levels are less frequently associated with specific conditions but may warrant further investigation if unexplained.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

NGAL Level

Frequently asked questions

What does a high NGAL level mean for my kidney health?
A high NGAL level suggests your kidneys may be under stress or damaged, which could be due to conditions like infections, heart problems, or kidney injury. Your doctor will use this along with other tests to determine the best course of action.
Can NGAL levels change over time, and how often should I get retested?
Yes, NGAL levels can fluctuate depending on your health status. Your doctor may recommend retesting if you’re recovering from surgery, have an ongoing condition affecting your kidneys, or if symptoms like fatigue or reduced urine output persist.
Is there anything I can do at home to help manage NGAL-related concerns?
While NGAL itself isn’t something you can directly manage, maintaining good kidney health—such as staying hydrated, controlling blood pressure, and managing chronic conditions like diabetes—can support overall kidney function. Always follow your doctor’s advice for personalized care.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy