Skip to content

Pneumococcal Nucleic Acid Detection (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from *Streptococcus pneumoniae* (pneumococcus) bacteria in your blood or plasma, often used to diagnose serious infections like pneumonia or sepsis.

Quick summary

["Helps identify pneumococcal infections quickly for faster treatment decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53917-1
Short code
S pneum DNA Bld Ql NAA+probe
Synonyms
S pneum DNA Bld Ql NAA+probe
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects genetic material (nucleic acid) from *Streptococcus pneumoniae* bacteria. This is done using a specialized probe that binds to unique sequences in the bacterial DNA or RNA, confirming presence even if the bacteria aren’t yet growing in your blood.

How the Test Works

A small blood sample is drawn and processed to extract nucleic acids. The probe targets specific genetic markers unique to pneumococcal bacteria, allowing detection even in low concentrations.

When This Test Is Ordered

Your healthcare provider may order this test if you have symptoms like high fever, difficulty breathing, or signs of severe infection, especially if you’re at higher risk (e.g., elderly, immunocompromised, or with chronic lung disease).

What to Expect

You’ll receive a blood sample, which is sent to a lab. Results are typically available within 24 hours. This test is often used alongside other diagnostic tools, like blood cultures or chest X-rays.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Pneumococcal DNA Probe Test

Frequently asked questions

Why is this test important?
This test helps confirm a pneumococcal infection quickly, which is critical for starting appropriate antibiotics (like penicillin or cephalosporins) to treat the infection before cultures grow. Early detection can prevent complications like organ failure or death.
What does a positive result mean?
A positive result means genetic material from *Streptococcus pneumoniae* was found in your blood. This strongly suggests a pneumococcal infection, but further testing (like blood cultures) may be needed to confirm the bacteria and guide treatment.
What if I have a negative result?
A negative result means no genetic material from *Streptococcus pneumoniae* was detected in this sample. However, other bacteria or viruses could still be causing your symptoms. Your provider may recommend additional tests or different treatments.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy