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Cerebrospinal Fluid (CSF) Nucleic Acid Probe Test (for Pathogenic DNA)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of DNA from certain bacteria or viruses in your cerebrospinal fluid (CSF), which may indicate an infection like meningitis or encephalitis.

Quick summary

["Helps diagnose infections in the brain and spinal cord by detecting foreign DNA in fluid around the brain and spinal cord."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
82187-6
Short code
S pneum DNA CSF Ql NAA+n-prb
Synonyms
S pneum DNA CSF Ql NAA+n-prb
Category
coagulation
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

The test uses a specialized probe to detect DNA fragments from specific pathogens (such as bacteria like *Neisseria meningitidis* or viruses like herpes simplex virus) in your CSF. It does not measure a single substance but identifies genetic material that may suggest an infection.

Why Might This Test Be Ordered?

Your healthcare provider may recommend this test if you have symptoms like severe headache, stiff neck, fever, confusion, or neurological concerns that could indicate meningitis, encephalitis, or other brain/spinal infections.

How Is the Sample Collected?

A small amount of CSF is collected through a procedure called a lumbar puncture (spinal tap), where a needle is inserted into the lower back to draw fluid from the spinal canal.

What Does a Positive Result Mean?

A positive result indicates the presence of pathogen DNA in your CSF, which strongly suggests an infection. Further testing or clinical evaluation will determine the exact cause and guide treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is primarily used as a diagnostic tool to quickly identify potential infections in the central nervous system. It complements other tests like blood cultures or CSF cultures and helps guide urgent treatment decisions.

Short name

CSF DNA Probe Test

Frequently asked questions

What does a positive result mean for my health?
A positive result suggests an infection may be present in your brain or spinal fluid, but it does not confirm the exact type of infection. Your doctor will work with you to determine the next steps, which may include additional tests or treatments.
How soon will I get results?
Results are typically available within a few days, depending on lab processing times. Your healthcare provider will discuss the findings with you during your follow-up visit.
Can I eat or drink before this test?
You may eat and drink normally before the test, but you should avoid caffeine or alcohol in excess, as they might affect your symptoms. Follow your doctor’s specific instructions for preparation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy