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Pneumococcal Nucleic Acid Detection in Respiratory Fluid (PCR-based)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic material from *Streptococcus pneumoniae* (pneumococcus) bacteria in your respiratory secretions, such as sputum or nasal swabs, using PCR technology. It helps determine if you may have a pneumococcal infection.

Quick summary

["Assists in diagnosing possible pneumococcal pneumonia or other respiratory infections quickly."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
106607-5
Short code
S pneum DNA Fld Ql NAA+n-prb
Synonyms
S pneum DNA Fld Ql NAA+n-prb
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
non-probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test detects the presence of pneumococcal DNA fragments in your respiratory fluid. Even small amounts of the bacteria’s genetic material can trigger a positive result, which helps confirm infection without needing to grow bacteria in a lab.

How the Test Works

PCR (Polymerase Chain Reaction) amplifies tiny traces of pneumococcal DNA from your sample. This process creates many copies of the genetic material, making it easier to detect even if the bacteria are present in low numbers.

Sample Collection and Preparation

Your provider will collect a sample (e.g., sputum, nasal swab, or throat swab) during a routine visit. The fluid from the sample is then processed to extract DNA for testing.

When This Test Is Ordered

Your doctor may recommend this test if you have symptoms like fever, cough, chest pain, or difficulty breathing—especially if they suspect pneumonia or another pneumococcal infection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Pneumococcal DNA Test

Frequently asked questions

How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times.
What does a positive result mean?
A positive result indicates the presence of pneumococcal DNA in your sample, which may mean you have an active infection. Your doctor will discuss next steps, such as starting antibiotics, based on your symptoms and test results.
Can I have this test if I’m not sick?
This test is primarily used to diagnose suspected infections. Routine screening for pneumococcal DNA in asymptomatic individuals is not standard unless symptoms or risk factors (e.g., weakened immune system) are present.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy