Serum or Plasma Protein Electrophoresis with Bromocresol Green (BCG) Dye Binding Assay
This test measures the distribution of proteins in your blood, including albumin and globulins, using a dye-binding method to assess protein patterns. It helps identify conditions affecting protein balance, such as infections, inflammation, or certain blood disorders.
["This test helps diagnose and monitor conditions affecting protein levels in your blood."]
Key facts at a glance
- LOINC
- 85769-8
- Short code
- S pyo DNA Bld Pos Ql NAA+n-prb
- Synonyms
- S pyo DNA Bld Pos Ql NAA+n-prb
- Category
- coagulation
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- non-probe-amp-tar
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your healthcare provider may order this test to investigate symptoms like unexplained weight loss, fatigue, swelling, or changes in blood test results. It’s also used to monitor conditions like multiple myeloma, liver disease, or kidney problems that alter protein production or breakdown.
What to Expect Before the Test
No special preparation is needed, but you may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Wear comfortable clothing for the blood draw, and let your provider know about any medications or medical conditions.
How the Test Is Performed
A small needle is inserted into a vein (usually in your arm), and blood is collected into a tube. The sample is then sent to a lab, where proteins are separated by gel electrophoresis and analyzed using the BCG dye to measure protein concentrations.
What the Results Mean
Results show the relative amounts of different protein fractions, such as albumin (the most abundant protein) and globulins (which include antibodies and other immune proteins). Abnormal patterns may indicate conditions like protein loss (e.g., nephrotic syndrome), overproduction (e.g., multiple myeloma), or liver/kidney dysfunction.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: This test is critical for diagnosing and managing conditions that disrupt normal protein balance. For example, abnormal electrophoresis can reveal monoclonal gammopathies (e.g., multiple myeloma), hypoalbuminemia (e.g., liver disease), or acute-phase reactants (e.g., infections). Early detection allows for targeted treatment and monitoring.
Short name
Protein Electrophoresis (BCG)
Frequently asked questions
What does an abnormal protein electrophoresis result mean?
How often should I get this test?
Can diet affect protein electrophoresis results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy