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Prostate-Specific Antigen (PSA) with Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Quantification

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of prostate-specific antigen (PSA) in your blood using advanced laboratory techniques to provide highly precise results. PSA is a protein produced mainly by the prostate gland, and its levels can help assess prostate health.

Quick summary

["PSA levels may indicate prostate health or potential concerns; precise measurement helps guide medical decisions."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88276-1
Short code
S pyogenes hsp60 Bld Pos Ql Probe
Synonyms
S pyogenes hsp60 Bld Pos Ql Probe
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test to monitor prostate health, especially if you have symptoms like urinary changes, pain in the pelvic area, or a history of prostate issues. It may also be used during screening for prostate cancer or after treatment to check for recurrence.

What to Expect Before the Test

No special preparation is needed, but avoid ejaculation for 2–3 days before the test if possible. Drink plenty of water to help your blood flow smoothly. If you have a prostate exam (like a digital rectal exam), schedule it before or after this blood draw to avoid confusion in results.

What Happens During the Test

A healthcare professional will draw blood from a vein in your arm. The blood sample will be sent to a lab for analysis using liquid chromatography-tandem mass spectrometry (LC-MS/MS), a highly sensitive method to detect PSA levels accurately.

What the Results Mean

Results are reported in nanograms per milliliter (ng/mL). While PSA levels can vary based on age, race, and health status, they are not the only factor considered in diagnosing prostate issues. Your doctor will interpret results in the context of your overall health and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PSA LC-MS/MS

Frequently asked questions

What does a high PSA level mean?
A high PSA level may suggest an enlarged prostate (benign prostatic hyperplasia), prostate inflammation (prostatitis), or prostate cancer. However, many men with low-risk prostate cancer have normal PSA levels, and other conditions can also raise PSA. Your doctor will discuss the full picture with you.
What does a low PSA level mean?
A low PSA level is less concerning but can occur in men with a smaller prostate, certain medications, or conditions like benign prostatic hyperplasia. It doesn’t rule out prostate cancer entirely, so further evaluation may be needed.
How often should I get this test?
Your doctor will determine the frequency based on your risk factors, symptoms, and medical history. Regular monitoring may be recommended for men with a history of prostate cancer, those at higher risk, or those undergoing prostate health surveillance.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy