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Serum or plasma substance concentration (e.g., protein or peptide) measured by immunoassay (CLIA)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a specific protein or peptide in your blood, often used to detect or monitor certain conditions like infections, autoimmune diseases, or protein-related disorders.

Quick summary

["Helps diagnose or track conditions affecting blood proteins or peptides."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12259-8
Short code
S pyog.enz Ab Ser Ql Shp Aggl
Synonyms
S pyog.enz Ab Ser Ql Shp Aggl
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
sheep-cell-aggl
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like unexplained weight changes, fatigue, swelling, or if they suspect conditions such as infections, kidney disease, or certain cancers. It could also be part of routine monitoring for chronic conditions like diabetes or liver disease.

What to Expect Before the Test

No special preparation is usually needed. You may fast for 8–12 hours before the test if instructed, but always follow your provider’s directions. Bring any medications you’re taking, as some may affect results.

During the Test

A small needle will be used to draw blood from a vein in your arm. You may feel a slight pinch, but the process is quick and typically painless. The blood sample will be sent to a lab for analysis.

What the Results Mean

Results will show the concentration of the measured protein or peptide. While reference ranges vary by lab, elevated or low levels may signal underlying health concerns that need further evaluation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Abnormal results could indicate conditions like protein-losing syndromes, infections (e.g., sepsis), autoimmune disorders (e.g., rheumatoid arthritis), or metabolic issues. Your provider will discuss findings in the context of your symptoms and medical history.

Short name

Protein/peptide level (serum/plasma)

Frequently asked questions

How long will I need to wait for results?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will contact you once they’re ready.
Can I eat or drink before this test?
Check with your provider first, as fasting may be required for some tests. If fasting isn’t needed, you can eat and drink normally unless instructed otherwise.
What if my results are outside the normal range?
Your provider will explain what the results mean and may recommend additional tests or treatments. Never interpret results independently—always discuss them with a healthcare professional.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy