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Serum or Plasma Immunoassay for Prostate-Specific Antigen (PSA) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of prostate-specific antigen (PSA), a protein produced mainly by the prostate gland, in your blood. PSA levels can help assess prostate health and detect potential issues like benign prostatic hyperplasia (BPH) or prostate cancer.

Quick summary

["PSA tests are often used to monitor prostate health and guide decisions about further evaluation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
22567-2
Short code
S pyog.enz Ab Titr Ser
Synonyms
S pyog.enz Ab Titr Ser
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your doctor may recommend a PSA test if you have symptoms like frequent urination, difficulty urinating, or pain in the pelvic area. It’s also used as part of routine screening for men at higher risk of prostate cancer, especially those with a family history or older age. Additionally, PSA levels may be checked after prostate surgery or radiation treatment to monitor for recurrence.

What to Expect Before the Test

No special preparation is needed for this blood test. You may have a small needle inserted into your arm, and a blood sample will be drawn. It usually takes a few minutes. If you’re on a blood thinner, let your doctor know before the test.

What the Results Mean

PSA levels can vary widely based on age, overall health, and medical conditions. While higher levels may raise concerns about prostate cancer, they can also be influenced by other factors like prostate inflammation, infection, or an enlarged prostate. Your doctor will interpret the results in the context of your overall health and symptoms.

Common Causes of Elevated PSA Levels

Elevated PSA levels can occur due to benign conditions such as an enlarged prostate, prostate infection, or recent prostate procedures. However, it’s important to note that prostate cancer can also cause elevated PSA levels. Further testing, like a digital rectal exam or biopsy, may be needed to determine the cause.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

PSA Level

Frequently asked questions

How often should I get a PSA test?
The frequency of PSA testing depends on your age, overall health, and risk factors. The U.S. Preventive Services Task Force recommends against routine PSA screening for men under 55 due to potential harms. For men aged 55–69, it’s a shared decision between you and your doctor, considering your risk factors. Men over 70 may not benefit as much from PSA screening due to life expectancy.
What does a PSA level of 4 ng/mL mean?
A PSA level of 4 ng/mL is within the range considered ‘normal’ for many men, but it’s not definitive. This value can be influenced by age, overall health, and other conditions. Your doctor will discuss the results with you and may recommend additional tests to understand the cause.
Can diet or supplements affect PSA levels?
Yes, certain foods and supplements, such as cruciferous vegetables (like broccoli and Brussels sprouts) or saw palmetto, may influence PSA levels. It’s best to discuss any dietary changes or supplements with your doctor before the test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy