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Substance concentration of orosomucoid protein in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that can help assess liver function and inflammation. It may also be used to monitor certain conditions affecting the liver or immune system.

Quick summary

["This test helps evaluate liver health and inflammation levels in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5036-9
Short code
S pyo rRNA Spec Ql Probe
Synonyms
S pyo rRNA Spec Ql Probe
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to check for liver disease, such as hepatitis or cirrhosis, or to monitor conditions like chronic inflammation. It can also be part of a broader evaluation for autoimmune disorders or other systemic conditions affecting protein production.

What Does This Test Measure?

Orosomucoid (also called alpha-1 acid glycoprotein) is a protein produced by the liver. Elevated levels may indicate inflammation, infection, or liver issues, while lower levels could suggest certain immune or metabolic conditions.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The blood is then processed to separate serum or plasma, where the protein is measured using a specialized lab technique.

What Are Possible Results?

Results are not provided in absolute numbers here, as reference ranges vary by lab and individual health. Your provider will interpret the results in the context of your medical history and other tests.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test supports diagnosis and monitoring of liver disease, inflammation, and certain immune-related conditions. Elevated levels may signal acute or chronic inflammation, while persistently low levels could warrant further investigation into metabolic or immune disorders.

Short name

Serum Orosomucoid (Alpha-1 Acid Glycoprotein)

Frequently asked questions

What causes elevated orosomucoid levels?
Elevated orosomucoid levels are often linked to inflammation, infections (such as pneumonia or hepatitis), or autoimmune diseases. Liver conditions like cirrhosis or chronic hepatitis may also raise these levels.
What causes low orosomucoid levels?
Low orosomucoid levels may occur in conditions affecting protein synthesis, such as malnutrition, severe liver disease, or certain genetic disorders. Rarely, it could be due to medications or metabolic disorders.
How often should this test be repeated?
Your provider will determine the frequency based on your condition. Some patients may need retesting every few months or annually, depending on their treatment plan and symptoms.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy