Skip to content

Urine squamous cell carcinoma antigen (SCC-Ag) screening

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein found in urine that may help detect squamous cell cancer of the urinary tract, such as bladder cancer.

Quick summary

["A urine SCC-Ag test may assist in early detection of certain types of bladder or upper urinary tract cancers."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
11277-1
Short code
Squamous #/area UrnS HPF
Synonyms
Squamous #/area UrnS HPF
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microscopy-light-hpf
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is This Test Measuring?

The test looks for squamous cell carcinoma antigen (SCC-Ag), a protein produced by squamous cells, which are a type of skin cell that can sometimes form cancer in the urinary tract. Elevated levels may suggest the presence of squamous cell cancer, though they are not definitive on their own.

Why Might You Need This Test?

Your healthcare provider may order this test if you have symptoms like blood in urine, persistent urinary issues, or if you have a history of urinary tract cancers. It may also be used as part of monitoring for known cancer or after treatment to check for recurrence.

How Is the Test Performed?

A simple urine sample is collected, typically during a routine urinalysis or at a clinic. The sample is then analyzed in a lab using immunoassay techniques to detect SCC-Ag levels.

What Do Results Mean?

Results are qualitative (positive or negative) rather than quantitative, meaning they indicate whether the protein was detected above a certain threshold. Positive results warrant further evaluation, such as additional imaging or biopsy, to confirm cancer.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine SCC-Ag screening

Frequently asked questions

How often will I need this test?
This test is primarily used as a screening tool or during monitoring phases, not as a routine check. Your doctor will determine the frequency based on your medical history, symptoms, and treatment plan.
What are the typical reference ranges?
Since this is a qualitative test, there are no numeric reference ranges provided. A positive result means SCC-Ag was detected, while a negative result means it was not.
Can false positives or negatives occur?
Yes, like many screening tests, false positives or negatives can happen. False positives may occur due to benign conditions or other factors, while false negatives could mean cancer is present but not detected by this test alone. Follow-up testing is essential for accurate diagnosis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy