Urine squamous cell carcinoma antigen (SCC antigen) screening

What This Test Measures

The test looks for squamous cell carcinoma antigen (SCC antigen), a protein produced by certain types of cancer cells. While SCC antigen is most strongly associated with bladder cancer, it can also appear in other squamous cell cancers, such as those in the urethra or prostate (in men). This protein may also be present in non-cancerous conditions like chronic bladder inflammation or infection.

Why It Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like blood in urine, frequent urination, pain during urination, or if you’re at higher risk for bladder cancer due to factors like smoking, long-term catheter use, or exposure to certain chemicals.

Who Might Need This Test

This screening is often considered for individuals with symptoms of urinary tract issues or those at increased risk for squamous cell cancer, though it is not a standard screening test for all cancer types.

What to Expect Before the Test

No special preparation is needed. You’ll provide a urine sample, typically collected in a clean container at home or during a clinic visit. Follow any specific instructions your provider gives you to ensure accurate results.