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Serum or Plasma Creatinine Concentration (Substance Concentration)

Published: August 9, 2026Updated: August 17, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood or urine. It helps assess how well your kidneys are filtering blood.

Quick summary

["A creatinine test helps check kidney function by measuring waste in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
102768-9
Short code
S rectivirgula IgE RAST
Synonyms
S rectivirgula IgE RAST
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
rast
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Matters

Your kidneys normally filter waste products from your blood, including creatinine. If your kidneys aren’t working well, creatinine levels in your blood may rise. This test helps doctors monitor kidney health, especially if you have conditions like diabetes, high blood pressure, or a history of kidney problems.

What to Expect Before the Test

You may have this test done by drawing blood from a vein in your arm. If testing urine creatinine is needed, you’ll collect a sample in a container at home or during a clinic visit. Avoid excessive exercise or heavy meals 24 hours before blood testing to get accurate results.

How the Test Works

Blood creatinine levels are measured using a lab technique that detects the substance’s concentration. Urine creatinine tests check how much creatinine passes through your urine over a set period (often 24 hours). This helps determine how well your kidneys are filtering waste.

What the Results Mean

Higher than expected creatinine levels may suggest kidney problems, while lower levels could indicate dehydration or muscle loss. Your doctor will compare your results to your age, sex, and overall health to interpret them correctly.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Creatinine

Frequently asked questions

What causes elevated creatinine levels?
Elevated creatinine levels may be caused by kidney disease, dehydration, severe muscle injury, or conditions that reduce blood flow to the kidneys. Low levels could result from dehydration, malnutrition, or certain medications.
Can diet affect creatinine levels?
Yes, diet can influence creatinine levels. High-protein foods or muscle breakdown (e.g., from intense exercise) may temporarily raise creatinine. Your doctor may ask about your diet if results seem unusual.
How often should I get this test?
Your doctor will determine how often you need this test based on your health history, symptoms, and kidney function. Regular monitoring may be needed if you have chronic conditions like diabetes or high blood pressure.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy