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Serum or Plasma Substance Concentration for Anti-Cardiolipin Antibodies (IgG)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of antibodies your body produces against cardiolipin, a fatty substance found in cell membranes. These antibodies may be linked to certain autoimmune conditions or blood clotting issues.

Quick summary

["This test helps assess potential autoimmune or clotting disorders by detecting unusual antibody activity against cardiolipin."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10361-4
Short code
ssDNA IgM Ser-aCnc
Synonyms
ssDNA IgM Ser-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms or risk factors for conditions like lupus, antiphospholipid syndrome, or other autoimmune diseases. It could also be part of a broader evaluation for unexplained blood clots or recurrent miscarriages.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast for 8–12 hours before the test if your blood is drawn early in the morning. Bring any medications you’re currently taking to your appointment.

What the Test Involves

A healthcare professional will draw blood from a vein in your arm. The blood sample is then sent to a lab for analysis using an immunoassay method to detect specific antibodies against cardiolipin.

What the Results Mean

Results are typically reported as a concentration level of the antibodies. Elevated levels may suggest an autoimmune response, but they don’t diagnose a specific condition alone. Your provider will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Anti-Cardiolipin Antibodies (IgG)

Frequently asked questions

What Does Elevated or Low Results Indicate?
Elevated antibody levels may be associated with autoimmune diseases like lupus or antiphospholipid syndrome, which can increase the risk of blood clots or other complications. However, not all elevated results indicate a problem, and further testing may be needed to clarify the cause.
How Might My Results Affect My Treatment?
If your results are abnormal, your healthcare provider may recommend additional tests or treatments to manage symptoms or reduce risks. For example, blood thinners might be prescribed if clotting is suspected. Always follow your provider’s guidance based on your specific situation.
Can I Take Anything Before or After the Test?
You can typically resume your normal activities right after the blood draw. Avoid taking any new medications without consulting your provider unless directed otherwise. If you have questions about timing, ask your lab technician or provider before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy