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Methicillin-Resistant Staphylococcus aureus (MRSA) or Vancomycin-Resistant Enterococcus Species

Published: August 9, 2026Updated: August 17, 2026

Identifies resistant bacteria that can cause difficult-to-treat infections and may require antibiotic treatment guided by laboratory susceptibility results.

Quick summary

A positive result means an infection-causing bacterium has resistance to an important antibiotic and treatment may need to be adjusted.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
54789-3
Short code
STAPHYLOCOCCUSAUREUSMETHICILLINRESISTANTORENTEROCOCCUSSPECIESVANCOMYCINRES
Synonyms
—
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
mdsv
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This test detects methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus species, often called VRE. These bacteria can resist commonly used antibiotics, making infections harder to treat.

Why might I need this test?

Testing may be ordered when there is concern about a resistant infection, during outbreaks, or when screening is needed in certain healthcare settings. It can also help determine which antibiotics are likely to be effective.

How is the test performed?

A clinical specimen, such as blood, urine, a wound swab, or another sample, is collected and tested by the laboratory. The exact testing method depends on the specimen and the test ordered, and results may be based on culture or another validated method.

How do I prepare for the test?

No special preparation is usually required. Follow any instructions provided by your healthcare professional, particularly if the test involves collecting a urine or stool sample or if screening is being done before a procedure.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result indicates that the tested sample contains MRSA or vancomycin-resistant Enterococcus. This may represent a true infection or colonization, depending on the specimen and clinical findings. Resistant infections may require different antibiotic choices and additional infection-control precautions, so results should be interpreted with the rest of the medical evaluation.

Short name

MRSA or VRE testing

Frequently asked questions

Does a positive result mean I have an infection?
Not always. A resistant bacterium may be causing an infection, or it may simply be present on a surface or in a screening specimen. Your healthcare professional will interpret the result with your symptoms and other test findings.
Are MRSA and VRE the same thing?
No. MRSA is a strain of Staphylococcus aureus that resists methicillin and many related antibiotics. VRE describes Enterococcus species that have developed resistance to vancomycin.
Can resistant bacterial infections still be treated?
Yes. Several other antibiotics may still be effective, and the laboratory can perform additional susceptibility testing when needed. Treatment should be selected by a healthcare professional based on the organism, infection site, and patient factors.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy