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Serum or plasma concentration of total protein by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of protein in your blood, which includes albumin and other proteins like globulins. Proteins help maintain fluid balance, support immune function, and transport nutrients.

Quick summary

["Your blood protein levels can signal overall health or potential issues like dehydration, liver disease, or kidney problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10092-5
Short code
ST I-Amp 6ms L-V5
Synonyms
ST I-Amp 6ms L-V5
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Total Protein Used For?

Blood protein levels are often checked to assess hydration status, detect liver or kidney disease, or evaluate nutritional health. Doctors may also use this test to monitor conditions like chronic kidney disease or severe infections.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab where protein concentration is measured using nephelometry, a technique that detects light scattering from proteins in the sample.

What Are Common Reasons for Testing?

Your healthcare provider might order this test if you have symptoms like swelling, unexplained weight loss, fatigue, or if they suspect conditions like liver disease, kidney disease, or malnutrition.

What Might Abnormal Results Indicate?

Low protein levels may suggest malnutrition, liver disease, kidney problems, or excessive fluid loss. High protein levels could indicate dehydration, multiple myeloma, or severe infections.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Total protein levels are a broad measure and can reflect underlying health conditions that require further evaluation. Doctors may order additional tests to determine the exact cause of abnormal results.

Short name

Total Protein

Frequently asked questions

Why might my doctor ask for repeated total protein tests?
If you have a known condition like kidney disease, liver disease, or a chronic illness, repeated tests may help track how your body is responding to treatment or monitor disease progression over time.
What can I do to prepare for this test?
No special preparation is usually needed, but you may be asked to fast for a few hours before the test if it’s part of a broader metabolic panel. Avoid smoking or consuming alcohol for 24 hours before the test if instructed.
Does this test have any risks or side effects?
The most common side effect is a slight bruise or soreness at the needle insertion site. Rarely, there may be a reaction to the needle or blood draw, such as dizziness or fainting.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy