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Germline Mutation Analysis for STK11 (LKB1) Gene

Published: August 9, 2026Updated: August 16, 2026

This test checks for mutations in the STK11 gene, which may be linked to certain inherited conditions affecting metabolism or growth.

Quick summary

["A genetic test to identify possible inherited risks related to STK11 gene variants."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
53795-1
Short code
STK11 gene Mut Anl Bld/T
Synonyms
STK11 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of conditions like Bannayan-Riley-Ruvalcaba syndrome, Peutz-Jeghers syndrome, or unexplained growth abnormalities. It may also be used in research or genetic counseling contexts.

What to Expect Before the Test

You’ll need a blood sample drawn by a healthcare professional. No special preparation is typically required, but discuss any medications or health conditions with your provider beforehand.

What the Results Mean

Results will indicate whether a mutation was detected in the STK11 gene. A positive result means a variant was found, which may influence genetic counseling or further testing. A negative result means no obvious mutation was detected in this sample.

Common Conditions Associated with STK11 Mutations

Mutations in the STK11 gene are associated with rare genetic disorders, including conditions affecting the gastrointestinal tract, skin, and growth patterns. These may require specialized care and monitoring.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Genetic Testing for STK11 Mutations

Short name

STK11 Gene Mutation Screening

Frequently asked questions

How often will I need this test?
The need for repeat testing depends on your clinical situation. If this test is part of a family screening or research study, your provider will outline follow-up plans. For routine monitoring, results may be reviewed annually or as needed.
What does a positive result mean for my health?
A positive result means a variant in the STK11 gene was detected. This may help explain certain symptoms, guide genetic counseling, or inform decisions about family planning or further testing. Consult your healthcare provider for personalized interpretation.
Can lifestyle changes help if I have a STK11 mutation?
While lifestyle changes may not reverse genetic mutations, they can support overall health. Discuss personalized recommendations with your provider, such as diet, exercise, or monitoring for related symptoms, based on your specific condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy