Serum or Plasma Lipoprotein(a) Concentration

What Is Lipoprotein(a)?

Lipoprotein(a) is a unique lipoprotein particle that combines cholesterol with a distinct protein called apolipoprotein(a). Unlike regular cholesterol, Lp(a) is not affected by diet or exercise, making it a stable but potentially harmful marker for heart disease. It circulates in the blood and can build up in artery walls over time, contributing to plaque formation.

Why Might You Need This Test?

Your healthcare provider may order this test if you have a family history of heart disease, stroke, or blood clots, or if you have conditions like high cholesterol, hypertension, or diabetes. It may also be used to assess risk in people with unexplained cardiovascular symptoms or those undergoing risk stratification for surgery or other procedures.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is then sent to a lab for analysis using a specialized immunoassay method to measure Lp(a) concentration. Results are typically available within 24–48 hours.

What Do the Results Mean?

Higher levels of Lp(a) are associated with an increased risk of heart disease and blood clots. While there is no single reference range for everyone, elevated levels may prompt further evaluation or lifestyle recommendations to manage risk. Your doctor will interpret results in the context of your overall health and medical history.