Serum or Plasma Slope of Electrophoretic Mobility (for Protein Electrophoresis)

What Is This Test Used For?

Electrophoretic mobility slope testing is primarily used in the evaluation of protein electrophoresis results. It can help identify conditions where protein separation patterns deviate from normal, such as in diseases affecting protein synthesis (e.g., liver disease) or conditions causing abnormal protein breakdown (e.g., certain cancers).

How Is This Test Performed?

A blood sample is drawn and processed into either serum or plasma. The sample is then subjected to electrophoresis, a process that separates proteins based on their electrical charge and size. The slope of protein movement is measured and recorded. This test is often performed as part of a broader protein electrophoresis panel, which may also include visual inspection of bands for qualitative assessment.

Why Might You Need This Test?

You may need this test if your healthcare provider suspects a condition affecting protein levels or distribution, such as liver disease, kidney disease, multiple myeloma, or other disorders that alter protein metabolism. It may also be used to monitor treatment responses in patients with known protein-related disorders.

What Are Common Conditions Monitored With This Test?

While not a standalone diagnostic test, the electrophoretic mobility slope is often used alongside other protein electrophoresis findings to identify patterns that suggest conditions like hypoalbuminemia, dysproteinemias (e.g., monoclonal gammopathies), or systemic inflammatory states.