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Antibody Screening for SARS-CoV-2 (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test detects antibodies in your blood that your immune system produces in response to exposure to the virus that causes COVID-19. Antibodies can appear days to weeks after infection, helping your body fight the virus.

Quick summary

This test helps determine if you may have been previously exposed to COVID-19, even if you never had symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
97115-0
Short code
STUDENTINTHEFEWWEEKSBEFORECOVID19OUTBREAK
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
3.5
Ref high
5
Critical range
2.5 N/A – 6.5 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84132
SNOMED
110742001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

The test measures the presence of antibodies (specifically IgG and sometimes IgM) that your immune system creates after exposure to the SARS-CoV-2 virus. These antibodies are a sign that your body has encountered the virus, either through infection or vaccination.

How Is the Sample Collected?

A blood sample is taken from a vein in your arm by a healthcare professional. You may feel a small pinch when the needle is inserted, but the procedure is quick and usually not painful.

How Soon Can Results Be Available?

Results are typically available within 1 to 3 business days, depending on your healthcare provider’s lab turnaround time. Follow-up instructions from your provider will guide you on interpreting your results.

What Does a Positive Result Mean?

A positive result indicates the presence of antibodies against COVID-19, suggesting you may have been previously infected. This does not confirm a current infection but can help track past exposure, especially useful in understanding immunity or for research purposes.

Reference range

Adult: 3.5-5.0 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is primarily used for serological screening, which can help identify individuals who have developed immunity through prior infection. It is not a diagnostic tool for active COVID-19 infection. Positive results may inform vaccination decisions, research studies, or public health tracking but should be interpreted alongside clinical judgment and other tests if needed.

Short name

COVID-19 Antibody Test (Screen)

Frequently asked questions

When Might I Need This Test?
You may need this test if you have questions about past COVID-19 exposure, especially if you’ve had symptoms or were exposed to someone with COVID-19. Healthcare providers may also recommend it for research, vaccination studies, or in certain occupational or travel-related settings.
What Does a Negative Result Mean?
A negative result means the antibodies detected in this test were not present at the time of testing. This does not definitively rule out past exposure—antibodies may take time to develop. If you suspect past exposure, discuss further testing with your healthcare provider.
Can I Get This Test After Being Vaccinated?
Yes, antibody tests can be used to assess immune response after vaccination, though they are not a substitute for vaccination. Results may vary and should be discussed with your healthcare provider to understand your immunity status.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy