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Serum or Plasma Aldolase Activity (Mass Concentration)

Published: August 9, 2026Updated: August 16, 2026

This test measures the activity of aldolase, an enzyme involved in breaking down glucose in your body. It helps assess conditions affecting muscle, liver, or red blood cells.

Quick summary

["Aldolase can signal muscle damage, liver disease, or red blood cell disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10109-7
Short code
ST wave ED L-I
Synonyms
ST wave ED L-I
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Aldolase Used For?

Doctors may order aldolase to diagnose or monitor conditions like myopathies (muscle diseases), hemolytic anemia (red blood cell destruction), or liver issues. It can also help track disease progression or response to treatment.

Common Conditions Monitored

High aldolase levels may suggest muscle breakdown (rhabdomyolysis), liver inflammation (hepatitis), or certain blood disorders. Low levels are less common but could indicate severe muscle wasting or rare enzyme deficiencies.

How Is the Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where aldolase activity is measured using an enzymatic method to detect its presence and concentration.

What Does a Result Mean?

Results are not provided with specific reference ranges. Your doctor will interpret the result in relation to your symptoms, medical history, and other tests. Elevated levels may prompt further evaluation for underlying conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Aldolase

Frequently asked questions

Why might my aldolase test be ordered?
Your doctor may recommend this test if you have symptoms like muscle weakness, fatigue, or unexplained pain, or if you’re being evaluated for conditions like muscle disorders, liver disease, or blood disorders.
What are typical reference ranges?
Reference ranges vary by lab and may not be standardized. Your results will be compared to your own baseline or clinical context rather than a general range.
Can I eat or drink before this test?
Follow your doctor’s instructions, but generally, fasting is not required. Avoid alcohol or strenuous activity 24 hours before testing, as these may affect results.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy