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Suberate-to-Creatinine Ratio, Urine

Published: August 9, 2026Updated: August 16, 2026

This urine test measures suberate relative to creatinine, helping evaluate metabolic acid production while accounting for urine concentration.

Quick summary

["An unusual suberate-to-creatinine ratio may suggest changes in fatty acid or organic acid metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25135-5
Short code
Suberate/Creat Ur-sRto
Synonyms
Suberate/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of suberate, a dicarboxylic acid, in urine and compares it with the amount of creatinine. Creatinine is a waste product used to help account for how concentrated the urine is.

Why might I need this test?

The test may be used as part of an evaluation for a suspected inherited metabolic disorder, especially one involving fatty acid or organic acid metabolism. It is usually interpreted with other urine and blood test results rather than by itself.

How is the test performed?

A urine sample is analyzed in the laboratory to measure suberate and creatinine. The laboratory then calculates the ratio of suberate to creatinine in the sample.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional, including whether a first-morning or timed urine sample is required. Fasting is not usually necessary, but diet, supplements, and medicines may affect the result and should be reported to the care team.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urinary Suberate-Creatinine Ratio

Frequently asked questions

What does a urine suberate-to-creatinine ratio measure?
It measures the amount of suberate relative to creatinine in urine. This helps account for variations in urine concentration.
Does an abnormal result mean I have a metabolic disorder?
Not by itself. An abnormal result can reflect a metabolic condition, but diet, illness, and medicines can also affect it, so further evaluation may be needed.
Is fasting required for this test?
Fasting is generally not required, but collection timing and preparation can depend on the laboratory's instructions. Ask your healthcare professional whether any dietary or medication changes are needed.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy