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Succinate/Creatinine Ratio, Urine — Mass Spectrometry

Published: August 9, 2026Updated: August 16, 2026

A specialized urine test that measures succinate relative to creatinine to help evaluate possible disturbances in cellular energy metabolism.

Quick summary

["This urine test can help identify certain inherited metabolic disorders, but results require specialist interpretation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
108525-7
Short code
Succinate/Creat Msmt Ur
Synonyms
Succinate/Creat Msmt Ur
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures succinate, a substance involved in cellular energy production, in urine. Creatinine is measured at the same time so the amount of succinate can be adjusted for urine concentration.

Why might I need this test?

It may be ordered to evaluate suspected inherited metabolic disorders, especially when an newborn screening result is abnormal or symptoms suggest a problem with energy metabolism. It is generally interpreted together with other laboratory and genetic findings.

How is the test performed?

A urine sample is analyzed using mass spectrometry, a laboratory method that separates and measures small molecules. The laboratory may report the succinate amount, the creatinine amount, or a ratio between them.

How do I prepare for the test?

Follow the collection instructions provided by your healthcare professional. A first-morning urine sample may be requested, and the collection time should be recorded; fasting is usually not required unless specifically instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine succinate/creatinine ratio

Frequently asked questions

Is this the same as a routine newborn screening test?
No. It is usually a specialized follow-up urine test ordered after an abnormal screening result or when a metabolic disorder is suspected.
Why is creatinine included in the test?
Creatinine helps account for how concentrated or dilute the urine sample is. This allows the succinate measurement to be interpreted more reliably.
Does an abnormal result mean I have a genetic disorder?
Not necessarily. An abnormal result can have several causes and may require repeat testing, additional laboratory studies, or genetic evaluation before any diagnosis is made.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy