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Urine Succinylacetone/Creatinine Ratio — Screen

Published: August 9, 2026Updated: August 16, 2026

A urine screening test that measures succinylacetone relative to creatinine. It is used to help evaluate for tyrosinemia type 1, particularly in newborns and infants.

Quick summary

["An abnormal result may suggest tyrosinemia type 1 and should be confirmed with additional testing."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
25137-1
Short code
Succinylacetone/Creat Ur-sRto
Synonyms
Succinylacetone/Creat Ur-sRto
Category
kidney
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What is this test?

This test measures the amount of succinylacetone in urine and compares it with the amount of creatinine. Creatinine is used as a reference to account for how concentrated the urine is.

Why might I need this test?

Succinylacetone can build up when the body cannot properly break down tyrosine. This test is commonly used in newborn or infant screening and may also be used when symptoms suggest tyrosinemia type 1.

How is the test performed?

A urine sample is tested in the laboratory, usually to determine the succinylacetone-to-creatinine ratio. The result is considered a screening finding rather than a final diagnosis.

How do I prepare for the test?

Follow the laboratory's instructions for urine collection, including the preferred container, timing, and amount needed. No special diet or fasting is usually required, but the testing center may provide specific instructions for infants.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Urine Succinylacetone/Creatinine Ratio

Frequently asked questions

Does an abnormal screening result mean my child has tyrosinemia?
Not necessarily. The result identifies possible metabolic disease and must be confirmed with follow-up laboratory and genetic testing.
Why is the result reported as a ratio to creatinine?
Urine concentration varies from sample to sample. Comparing succinylacetone with creatinine helps the laboratory interpret how much succinylacetone is present relative to the amount of urine collected.
What symptoms can occur with tyrosinemia type 1?
Early signs may include poor feeding, vomiting, weight loss, yellowing of the skin or eyes, and increasing liver problems. Some affected infants may not have obvious symptoms, which is why screening is important.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy