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Sucrose Hemolysis Index (Serum/Plasma)

Published: August 9, 2026Updated: August 17, 2026

This test measures how quickly red blood cells break down (hemolyze) in the presence of sucrose, which helps assess blood compatibility for transfusions.

Quick summary

["Helps determine if your blood is safe for donation or transfusion by checking red blood cell stability."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
40433-5
Short code
Sucrose Hemolysis NFr Cont RBC
Synonyms
Sucrose Hemolysis NFr Cont RBC
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.2
Ref high
5.9
Critical range
2 N/A – 7 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
85041
SNOMED
900000000000003001
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test involves mixing your blood with a sucrose solution. Healthy red blood cells remain intact, while those prone to hemolysis (e.g., due to certain conditions or genetic factors) break down more easily. The resulting hemolysis index indicates how stable your red blood cells are.

Why It’s Done

Doctors may order this test if you’re a blood donor, have a history of hemolytic reactions, or if your blood type requires cross-matching to ensure compatibility during transfusions.

Sample Collection

A small blood sample is drawn from a vein, typically in the arm. The blood is then processed to separate serum or plasma for testing.

Preparation

No special preparation is needed. You may eat or drink as usual, but inform your doctor about any medications or supplements you’re taking, as they could affect blood components.

Reference range

Adult males: 4.2-5.9; Females: 3.8-5.1 x 10^12/LN/A

Specimen: serum

No special preparation required. Stay well hydrated.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Sucrose Hemolysis Test

Frequently asked questions

A high hemolysis index may suggest inherited or acquired conditions affecting red blood cell stability, while a low index indicates normal compatibility. This test is critical for transfusion safety and donor screening.
This test is primarily used to screen blood for transfusion compatibility or to evaluate red blood cell integrity in donors. It does not diagnose specific diseases but helps guide medical decisions.
How long does it take to get results from this test?
Results are typically available within 1–2 business days, depending on your lab’s processing schedule. Follow-up with your healthcare provider if you have questions about your results.
Can I donate blood if this test is abnormal?
If your hemolysis index is elevated, you may need further evaluation by a blood bank specialist. They will determine eligibility based on clinical context and other factors, not just this single test result.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy