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Surfactant Protein C (SP-C) Genetic Mutation Screening (Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for genetic changes in the SP-C gene, which may affect how your lungs produce surfactant—a substance that helps keep your airways open. Some mutations can increase your risk of lung diseases like pulmonary fibrosis.

Quick summary

["Genetic screening helps identify potential risks for lung conditions that may require early monitoring or management."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
43750-9
Short code
SURF1 gene Mut Anl Bld/T
Synonyms
SURF1 gene Mut Anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
CPT
86430
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have a family history of lung diseases, unexplained lung symptoms, or if you’re considering genetic counseling. It may also be used in research or as part of a broader genetic evaluation.

What to Expect Before the Test

You’ll need a simple blood draw, usually taken from your arm. No special preparation is required, but tell your doctor about any medications or conditions that could affect results.

What the Test Measures

The test detects specific mutations in the SP-C gene, which encodes surfactant protein C. These mutations can alter protein function and may contribute to lung diseases like idiopathic pulmonary fibrosis (IPF).

How Results Are Used

Results help determine if you’re at higher risk for lung diseases. If mutations are found, your provider may recommend further testing, lifestyle adjustments, or monitoring to manage symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Mutations in the SP-C gene are associated with increased susceptibility to chronic lung diseases, particularly those involving fibrosis (scarring) of lung tissue. Early identification may support proactive care strategies, though treatment options are still evolving.

Short name

SP-C Gene Mutation Test

Frequently asked questions

Will this test show all possible lung diseases?
No, this test specifically checks for SP-C gene mutations linked to certain lung conditions. Other genetic or environmental factors may also contribute to lung health, so results should be discussed with your healthcare provider.
How long will it take to get results?
Results typically take 1–4 weeks, depending on lab processing and follow-up steps. Your provider will contact you once available.
Can I eat or drink before the blood draw?
You can eat normally, but avoid heavy meals right before the draw. Drink water as usual unless instructed otherwise.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy