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Syphilis serology (screening and confirmatory) during pregnancy

Published: August 9, 2026Updated: August 17, 2026

This test checks for syphilis antibodies in your blood to monitor your health and the safety of your baby during pregnancy.

Quick summary

Early detection helps manage syphilis and prevent complications for both you and your baby.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
75181-8
Short code
SURVEILLANCESTAGEOFSYPHILISDURINGPREGNANCY
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Critical range
0.5 N/A – —
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cdc-cs
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have risk factors for syphilis, such as multiple sexual partners, a history of sexually transmitted infections (STIs), or exposure to someone with syphilis. It is also part of routine prenatal care to ensure timely treatment if syphilis is present.

How the Test Works

The test uses blood drawn from a vein to detect antibodies against syphilis bacteria. Two types of tests are often performed: a screening test (qualitative) and a confirmatory test (if the screening is positive). These tests help identify whether syphilis is active or past infection.

What to Expect During the Test

You will lie down while a healthcare provider inserts a needle into your arm to collect a small amount of blood. The process takes a few minutes, and you may feel a brief pinch. The blood is then sent to a lab for testing.

What the Results Mean

Results may be positive, negative, or inconclusive. A positive result means syphilis antibodies are present, which could indicate past or current infection. Follow-up testing or treatment may be recommended based on the results.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Syphilis test (pregnancy)

Frequently asked questions

What does a positive test result mean?
A positive result means your body has detected antibodies to syphilis, which could indicate an active infection or past exposure. Your healthcare provider will discuss next steps, such as additional testing or treatment, to ensure your health and your baby’s safety.
How often should I get this test during pregnancy?
Your healthcare provider will determine the timing based on your medical history and risk factors. Typically, it may be done at your first prenatal visit and again during the third trimester if needed.
Can I take anything special before this test?
No special preparation is needed. However, inform your healthcare provider about any medications you’re taking or recent illnesses to ensure accurate results.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy