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Serum or Plasma Alpha-1 Antitrypsin (A1AT) Concentration

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of Alpha-1 Antitrypsin, a protein produced by the liver that helps protect the lungs from damage caused by enzymes released during inflammation.

Quick summary

["Alpha-1 Antitrypsin helps maintain lung health and can be low in conditions affecting the lungs or liver."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
10035-4
Short code
S wave Amp L-AVL
Synonyms
S wave Amp L-AVL
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ekg
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms like chronic cough, shortness of breath, or liver issues, or if you have a family history of lung diseases like emphysema or chronic obstructive pulmonary disease (COPD). It may also be checked before surgeries or procedures involving the lungs or liver.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm. If you’re taking blood thinners, let your provider know before the test.

What the Test Results Mean

Results help determine if your Alpha-1 Antitrypsin levels are low, which could indicate a genetic disorder or other health conditions affecting protein production. Very low levels may require further testing or monitoring.

Common Conditions Linked to Low Levels

Low Alpha-1 Antitrypsin levels are often linked to genetic disorders like Alpha-1 Antitrypsin Deficiency, which can cause lung diseases or liver problems. It’s important for early detection and management.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Alpha-1 Antitrypsin Level

Frequently asked questions

What causes low Alpha-1 Antitrypsin levels?
Low levels can be caused by genetic mutations, liver disease, or certain medications. If you have a family history of lung or liver disease, your provider may check this test as part of preventive care.
How often should I get this test?
Your provider will decide based on your health history and symptoms. If you have a known deficiency, follow their recommendations for regular monitoring.
Can diet or supplements affect this test?
Dietary changes or supplements generally do not affect Alpha-1 Antitrypsin levels directly. However, if you’re on medications, always check with your provider before starting new supplements.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy