Serum or Plasma Waveform Amplitude (for Electrophoresis)

What Is This Test Used For?

Electrophoresis is commonly used to separate proteins in blood, such as albumin and globulins. Waveform amplitude can help detect conditions like multiple myeloma, liver disease, or other protein-related disorders. Some labs may also use this data to monitor treatment responses or screen for genetic conditions affecting protein synthesis.

How Is This Test Performed?

A small blood sample is drawn, and the serum or plasma is placed in an electric field. The proteins move at different speeds based on their charge, creating a waveform pattern. The amplitude of this waveform reflects the concentration and distribution of proteins, which is then analyzed by a lab technician or computer.

What Does a Result Mean?

While waveform amplitude itself doesn’t provide direct numeric values for individual proteins, it may be used alongside other electrophoresis results to identify abnormal patterns. For example, a high amplitude in certain regions might suggest an overproduction of specific proteins, which could indicate conditions like monoclonal gammopathy or liver dysfunction. Your healthcare provider will interpret results in the context of your full medical history and other tests.

Common Conditions Monitored

This test is sometimes used as part of a broader protein electrophoresis panel to monitor conditions like multiple myeloma (a cancer of plasma cells), Waldenström macroglobulinemia (a rare blood cancer), or hereditary protein disorders. It may also be part of liver function testing if protein synthesis is suspected to be impaired.