Serum or Plasma Aldolase Activity (Enzymatic Method)
This test measures the activity of aldolase, an enzyme involved in breaking down glucose in your body. It may be used to assess muscle damage or certain metabolic conditions.
["Aldolase helps identify muscle injury or metabolic disorders by measuring enzyme activity in blood."]
Key facts at a glance
- LOINC
- 10077-6
- Short code
- S' wave dur L-V2
- Synonyms
- S' wave dur L-V2
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- ekg
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Might Be Ordered
Your healthcare provider may order aldolase testing if you have symptoms like muscle weakness, pain, or fatigue, or if they suspect conditions such as muscle disorders, hemolytic anemia, or certain metabolic diseases. It can also be part of a broader evaluation for unexplained muscle damage or metabolic issues.
What to Expect Before the Test
No special preparation is usually needed. You may be asked to fast for a few hours before the test if it involves drawing blood from a vein. If you’re taking medications, let your provider know, as they may affect results.
What Happens During the Test
A healthcare professional will draw blood from a vein in your arm. The blood sample will be sent to a lab for analysis using an enzymatic method to measure aldolase activity.
What the Results Mean
Results may be compared to a reference range provided by your lab. Elevated aldolase levels can suggest muscle damage, inflammation, or certain metabolic disorders, while lower levels may indicate conditions like muscle atrophy or certain genetic metabolic diseases.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated aldolase levels can signal muscle injury (e.g., from trauma, infections, or inflammatory conditions), hemolytic anemia, or metabolic disorders like glycogen storage diseases. Lower levels may be associated with muscle wasting or rare metabolic conditions. Always discuss results with your provider for personalized interpretation.
Short name
Aldolase
Frequently asked questions
What causes aldolase levels to be high?
What does it mean if my aldolase level is low?
Can aldolase test results change over time?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy