Syphilis Serology Test (Qualitative Treponemal Antibody Detection)
This test checks for antibodies to the bacteria that cause syphilis, which may indicate past or current infection. It helps doctors confirm whether treatment was effective or if further action is needed.
["This test helps track syphilis exposure and treatment response."]
Key facts at a glance
- LOINC
- 75197-4
- Short code
- SYPHILISTREATMENTWASGIVENTREATMENTDESCRIPTION
- Synonyms
- —
- Category
- coagulation
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- cdc-cs
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Your doctor may order this test if you have symptoms of syphilis (such as sores, rashes, or flu-like illness), a history of syphilis exposure, or if you’re part of a group at higher risk. It can also be used to monitor treatment progress or check for reinfection.
What to Expect Before the Test
No special preparation is needed. A blood sample is taken from a vein in your arm. You may feel a small pinch, but it usually doesn’t cause discomfort afterward.
How the Test Works
The test detects antibodies produced by your immune system in response to *Treponema pallidum* (the bacteria causing syphilis). These antibodies are found in blood and can persist even after treatment, so this test is qualitative (yes/no) rather than measuring exact levels.
What the Results Mean
A positive result means antibodies were found, suggesting past or current syphilis infection. A negative result means no detectable antibodies, but this doesn’t always rule out syphilis—confirmatory tests may be needed.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Syphilis is treatable with antibiotics, but early detection is key. If you tested positive, your doctor will prescribe treatment. Follow-up tests may be done to ensure the infection is cleared. Persistent positive results could indicate reinfection or incomplete treatment, prompting further evaluation.
Short name
Syphilis Antibody Screen (Qualitative)
Frequently asked questions
What does a positive result mean for my health?
Can I still get syphilis if my test was negative?
How long does it take to get results?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy