T(12;16) DDIT3-FUS Fusion Gene, Blood
A genetic test that looks for the DDIT3-FUS fusion in blood DNA. It may support evaluation for certain soft-tissue tumors, including myxoid liposarcoma.
["This test checks blood DNA for a specific chromosome rearrangement associated with some soft-tissue tumors."]
Key facts at a glance
- LOINC
- 21781-0
- Short code
- t(12;16)(DDIT3,FUS) NFr Bld/T
- Synonyms
- t(12;16)(DDIT3,FUS) NFr Bld/T
- Category
- thyroid
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 80
- Ref high
- 200
- Critical range
- 20 N/A – 400 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- CPT
- 84436
- SNOMED
- 302346007
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What is this test?
This test examines DNA from a blood sample for a fusion involving the DDIT3 and FUS genes. The fusion results from a rearrangement of chromosomes 12 and 16, written as t(12;16).
Why might I need this test?
The DDIT3-FUS fusion is most strongly associated with myxoid liposarcoma, a type of soft-tissue tumor. Testing may be used when symptoms, imaging, or other laboratory findings suggest this diagnosis.
How is the test performed?
A blood sample is collected, and the laboratory examines its DNA for the DDIT3-FUS fusion. The test code does not specify the exact laboratory method, so the ordering clinician or laboratory can explain how it will be analyzed.
How do I prepare for the test?
No special preparation is usually required, and fasting is generally unnecessary. Follow any instructions from the laboratory and tell the care team about a recent blood transfusion or stem-cell transplant, which may affect genetic test results.
Reference range
Adult: 80-200 ng/dLN/A
Take your thyroid medication after the blood draw if applicable. No fasting required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Detecting the DDIT3-FUS fusion can strongly support a diagnosis of t(12;16)-positive disease, particularly myxoid liposarcoma, when combined with the clinical and pathology findings. A negative result means the fusion was not detected in the tested blood sample but does not completely exclude a fusion-related tumor. Results should therefore be interpreted by the ordering clinician alongside imaging, tissue testing, and other evidence.
Short name
DDIT3-FUS Fusion Gene Test
Frequently asked questions
What does a positive DDIT3-FUS result mean?
Does a negative result rule out myxoid liposarcoma?
Why is a blood sample used for a tumor-related test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy