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Serum or Plasma Total Protein with Albumin-to-Globulin Ratio (A/G Ratio)

Published: August 9, 2026Updated: August 16, 2026

This test measures your total protein levels in blood and evaluates the balance between albumin and globulin proteins, which can help assess protein status and potential conditions like malnutrition or liver/kidney disease.

Quick summary

["Your blood protein balance may indicate health risks or nutritional needs."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
79209-3
Short code
t(2;3)(PAX8,PPARG) Tiss Ql
Synonyms
t(2;3)(PAX8,PPARG) Tiss Ql
Category
coagulation
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does Total Protein Measure?

Total protein includes all proteins in your blood, primarily albumin and globulin. Albumin helps maintain fluid balance in your body, while globulins support immune function and transport substances like hormones. Together, they reflect overall protein synthesis and breakdown.

Why Is the Albumin-to-Globulin Ratio Important?

The A/G ratio compares albumin (a protein that keeps fluids in your blood vessels) to globulins (proteins linked to immunity and clotting). A higher ratio may suggest liver disease (low albumin), while a lower ratio could indicate malnutrition or chronic inflammation.

When Might This Test Be Ordered?

Your doctor may request this test if you have symptoms like swelling, unexplained weight loss, fatigue, or signs of liver/kidney problems. It’s also used to monitor conditions like cirrhosis, kidney disease, or malnutrition.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, usually in your arm. You may feel slight discomfort, but it’s brief. If you’re on blood thinners, inform your provider before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Total Protein & A/G Ratio

Short name

Total Protein & A/G Ratio

Frequently asked questions

How long will it take to get my results?
Results are typically available within 1–3 business days, depending on your lab. Your doctor will discuss them with you during your follow-up visit.
Can I eat or drink before this test?
You can eat and drink normally unless instructed otherwise. Avoid alcohol for 24 hours before testing if your provider advises it.
What if my results are outside the expected range?
If your results are abnormal, your doctor will explain the possible causes and next steps, such as further testing or lifestyle changes. Always discuss findings with your healthcare team.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy