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Serum/plasma mass concentration of a specific protein measured by high-performance liquid chromatography (HPLC)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of a particular protein in your blood using a specialized lab technique. It helps assess protein levels that may be important for diagnosing or monitoring certain health conditions.

Quick summary

["This test helps identify abnormal protein levels that could indicate underlying health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90797-2
Short code
T4 2h p levo SerPl-mCnc
Synonyms
T4 2h p levo SerPl-mCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.5
Ref high
12
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84436
SNOMED
302345006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test focuses on detecting the precise concentration of a protein in your blood. The method used, high-performance liquid chromatography (HPLC), separates and identifies proteins based on their size and chemical properties. This technique is highly sensitive and accurate for measuring small amounts of specific proteins.

Why It Matters

Protein levels can vary due to various health conditions, including genetic disorders, liver or kidney disease, or certain metabolic disorders. Detecting abnormal protein concentrations can help healthcare providers diagnose conditions early or monitor treatment effectiveness.

How It’s Done

A blood sample is drawn from a vein, typically in your arm. The blood is then processed to separate serum or plasma from blood cells. The protein of interest is analyzed using HPLC, which breaks down the sample into its components and measures their concentration.

Preparation for the Test

No special preparation is usually required, but you may be asked to avoid certain medications or foods for a few days before the test. Always follow your healthcare provider’s instructions to ensure accurate results.

Reference range

Adult: 4.5-12.0 μg/dLN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

What could abnormal results mean?
Abnormal protein levels detected by this test may suggest conditions such as genetic disorders, protein-related diseases, or metabolic imbalances. For example, certain proteins are linked to inherited conditions like lysosomal storage diseases or specific enzyme deficiencies. Your healthcare provider will discuss the results in the context of your overall health and symptoms.
How often should I get this test?
The frequency of this test depends entirely on your healthcare provider’s recommendations. Some patients may need routine monitoring, while others may only require testing if symptoms or risk factors suggest the need. Regular follow-ups with your doctor will help determine the best schedule for you.
Can I eat or drink before this test?
Typically, you can eat and drink normally before this test unless your healthcare provider advises otherwise. Blood tests like this are usually done on an empty stomach for some tests, but this test does not have specific dietary restrictions. Always check with your provider for personalized instructions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy