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Total Protein with Albumin Ratio (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test measures your blood’s total protein and albumin levels to help assess protein balance and potential kidney or liver function issues.

Quick summary

["A ratio that reflects protein health and organ function—key for detecting conditions like kidney disease or malnutrition."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14015-2
Short code
T4 PA Bnd/Prealb SerPl
Synonyms
T4 PA Bnd/Prealb SerPl
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
4.5
Ref high
12
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84436
SNOMED
302345006
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Your blood contains proteins like albumin and globulins, which support immunity, blood clotting, and fluid balance. This test evaluates the **total protein** (sum of all proteins) and the **albumin** (a key protein for fluid balance). The ratio helps doctors check if your kidneys or liver are working properly or if you have protein loss in urine (e.g., nephrotic syndrome).

Why Might You Need This Test?

Doctors may order this test if you have symptoms like swelling (edema), unexplained weight loss, fatigue, or signs of kidney/liver problems. It’s also used in monitoring chronic conditions like kidney disease, liver disease, or malnutrition.

How Is the Test Done?

A small blood sample is taken from your arm. The lab separates your blood into components and measures protein levels using standard lab techniques (often nephelometry or turbidimetry). Albumin is typically measured separately, and the ratio is calculated.

What Are Common Results?

Results show a **total protein** and **albumin** value, along with their ratio. While exact ranges vary by lab, a low ratio may suggest protein loss (e.g., kidney disease), while high levels could indicate dehydration or liver issues. Your doctor will interpret results in context with your health.

Reference range

Adult: 4.5-12.0 μg/dLN/A

Specimen: serum

Take your thyroid medication after the blood draw if applicable. No fasting required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Protein/Albumin Ratio

Frequently asked questions

What Causes Low Protein/Albumin Levels?
Conditions like kidney disease (e.g., nephrotic syndrome), liver cirrhosis, malnutrition, or severe infections can reduce albumin. Certain medications (e.g., diuretics) or chronic illnesses may also lower protein levels.
What Causes High Protein Levels?
Dehydration, severe infections, or conditions like multiple myeloma (bone marrow cancer) can raise total protein. High globulin levels may signal chronic inflammation or autoimmune diseases.
Can I Avoid This Test?
No, this test is often routine for monitoring chronic conditions or diagnosing kidney/liver issues. Follow your doctor’s advice for follow-ups or retests if needed.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy