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BCR/ABL Fusion Gene Detection by Qualitative PCR (Blood)

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of a genetic fusion between the BCR and ABL genes, often linked to certain blood cancers.

Quick summary

["Helps diagnose and monitor chronic myeloid leukemia (CML)."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
50014-0
Short code
t(9;22)(ABL1,BCR) Bld/T
Synonyms
t(9;22)(ABL1,BCR) Bld/T
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

The BCR-ABL fusion gene is a hallmark of chronic myeloid leukemia (CML), a type of blood cancer. Detecting it early is crucial for treatment planning and managing disease progression. This test helps doctors determine if your cancer is responding to treatment or if adjustments are needed.

How the Test Works

A small sample of your blood is taken and analyzed using polymerase chain reaction (PCR) technology. This method detects the specific genetic change that defines CML by identifying the BCR-ABL fusion sequence, which is not present in healthy cells.

Sample Collection

Blood is drawn from a vein, typically in your arm, using a needle. The sample is then processed in the lab for testing. This procedure is quick and usually requires no special preparation beyond standard precautions for blood draws.

Test Results Interpretation

Results are qualitative, meaning they indicate either the presence or absence of the BCR-ABL fusion gene. Positive results confirm CML or monitor disease activity in treated patients. Negative results suggest the absence of this genetic marker.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

BCR-ABL Test

Frequently asked questions

What does a positive result mean?
A positive result indicates the presence of the BCR-ABL fusion gene, strongly suggesting chronic myeloid leukemia (CML). This finding is critical for starting appropriate treatment and managing the disease effectively.
How often will I need this test?
If diagnosed with CML, you may need this test regularly during treatment to check how well your cancer is responding. Your doctor will determine the frequency based on your treatment plan and disease stage.
Can lifestyle changes affect this test?
Lifestyle factors like diet or exercise generally do not directly impact the BCR-ABL test results. However, following your doctor’s advice for managing your condition is important, as it may influence overall treatment decisions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy