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Bcr-Abl Fusion Protein Detection (Qualitative) by Immunoassay

Published: August 9, 2026Updated: August 16, 2026

This test checks for the presence of a genetic fusion protein (BCR-ABL) linked to certain blood cancers, such as chronic myeloid leukemia (CML).

Quick summary

["This test helps monitor cancer treatment effectiveness and response to therapy."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
21821-4
Short code
t(9;22)(ABL1,BCR) Bld/T Ql
Synonyms
t(9;22)(ABL1,BCR) Bld/T Ql
Category
coagulation
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

The BCR-ABL fusion protein is formed when parts of two genes (BCR and ABL) combine. This genetic change can drive abnormal blood cell growth in conditions like CML. The test detects this fusion to guide treatment decisions.

How the Test Works

Blood is drawn and analyzed using an immunoassay method to identify the BCR-ABL protein. If present, it confirms the genetic abnormality associated with the cancer.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications or recent illnesses. You may feel slight discomfort from the blood draw.

What to Expect After the Test

Results are typically available within days. Follow-up may include additional testing or adjustments to treatment based on the outcome.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for diagnosing, monitoring, and managing chronic myeloid leukemia (CML) and other related blood disorders. Detecting the BCR-ABL fusion helps determine the most effective treatment plan, including tyrosine kinase inhibitors, and assesses whether the cancer is responding to therapy.

Short name

BCR-ABL Test (Qualitative)

Frequently asked questions

How often will I need this test?
Your healthcare provider will determine the frequency based on your diagnosis and treatment plan. Regular monitoring may be needed during and after treatment to track changes in the cancer.
What does a positive result mean?
A positive result indicates the presence of the BCR-ABL fusion protein, confirming the genetic abnormality linked to your condition. This guides treatment decisions and helps assess response to therapy.
Can lifestyle changes affect this test?
While lifestyle factors like diet or exercise generally do not directly influence this specific test result, they may impact overall health and treatment response. Always discuss any concerns with your provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy