Bcr-Abl Break Apart Fusion Gene Test (by PCR)
This test checks for genetic changes in white blood cells that may indicate chronic myeloid leukemia (CML) or other blood disorders. It detects a specific rearrangement involving the BCR and ABL genes, which can help guide treatment decisions.
["This test helps diagnose or monitor blood cancers by looking for genetic mutations linked to abnormal cell growth."]
Key facts at a glance
- LOINC
- 75892-0
- Short code
- t(9;22)(ABL1,BCR) break pts Bld/T
- Synonyms
- t(9;22)(ABL1,BCR) break pts Bld/T
- Category
- coagulation
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 0.8
- Ref high
- 1.2
- Critical range
- — – 5 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- molgen
- CPT
- 85610
- SNOMED
- 396252006
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Doctors may order this test if you have symptoms of blood disorders, such as unexplained fatigue, weight loss, or frequent infections. It’s also used during treatment to check if the disease is responding or if it’s spreading. Some people get this test as part of routine monitoring after treatment begins.
How the Test Works
The test uses a small sample of blood to analyze DNA from white blood cells. Specialized lab techniques (like polymerase chain reaction, or PCR) identify whether the BCR and ABL genes are separated in a way that suggests a fusion gene, which is a hallmark of certain blood cancers.
Sample Collection and Preparation
A blood sample is drawn from your arm, usually in a clinic or lab. The blood is processed to isolate white blood cells, which are then tested for the genetic changes. No special preparation is needed before the test.
What to Expect After the Test
Results may take several days to a week, depending on lab processes. Your healthcare provider will discuss the results with you, explaining whether the test found the genetic changes and how they relate to your condition.
Reference range
INR: 0.8-1.2 (warfarin: 2.0-3.0)N/A
Inform your healthcare provider if you are taking blood thinners. No special preparation required.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results for the BCR-ABL fusion gene strongly suggest chronic myeloid leukemia (CML) or other related blood disorders. This genetic marker helps doctors confirm the diagnosis, determine the appropriate treatment, and monitor disease progression or response to therapy. Early detection and targeted treatment can improve outcomes and quality of life.
Short name
BCR-ABL Break Apart Test
Frequently asked questions
What does a positive result mean?
Will this test affect my treatment plan?
How often will I need this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy